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Preventive effects of diets supplemented with sweetie fruits in
hypercholesterolemic patients suffering from coronary artery disease
Shela Gorinstein, Ph.D.,a,* Abraham Caspi, M.D.,b Imanuel Libman, M.D., Ph.D.,b
Elena Katrich, M.Sc.,a Henry Tzvi Lerner, Ph.D.,b and Simon Trakhtenberg, M.D., Ph.D., D.Sc.b
a Department of Medicinal Chemistry and Natural Products, The Hebrew University of Jerusalem-Hadassah Medical School,
P.O.B. 12065, Jerusalem 91120, Israel
b Institute of Cardiology, Kaplan University Medical Center, Rehovot, Israel
Available online 21 February 2004
Abstract
Background. Diets rich in vegetables and fruits prevent development of atherosclerosis.
Objective. To investigate the preventive effects of diets supplemented with a new kind of citrus fruit—pummelo–grapefruit hybrid in
hypercholesterolemic patients suffering from coronary artery disease (CAD).
Subjects and methods. Sixty-six hypercholesterolemic volunteers after coronary bypass surgery ages 47–68 years were randomly divided
into two experimental (EG1 and EG2) groups and one control (CG) group, 22 each. The diets of the patients of the experimental groups (EG1
and EG2) were supplemented with one or two peeled sweeties, respectively. A comprehensive clinical investigation of all 66 patients was
done. Blood samples were collected before and after the investigation for a wide range of laboratory tests.
Results. A high content of dietary fibers and antioxidant compounds in peeled sweeties was found. After 30 days of the investigation,
peeled sweeties-supplemented diets have decreased plasma lipids levels in EG1 and EG2 vs. CG group: (a) total cholesterol (TC)—7.38 vs.
8.08 mmol/L, 8.7%, and 6.78 vs. 8.08. mmol/L, 16.1%, respectively; (b) low-density lipoprotein cholesterol (LDL-C)—5.65 vs. 6.39
mmol/L, 1.6%, and 5.04 vs. 6.39 mmol/L, 21.2%, respectively; (c) triglycerides (TG)—2.01 vs. 2.27 mmol/L, 11.5%, and 1.71 vs.
2.27 mmol/L, 24.7%, respectively. In addition, a significant increase in the plasma antioxidant capacity in EG2, and to a lesser degree in
EG1 groups, was observed. No changes in the studied indices in the patients of the CG were detected.
Conclusion. Peeled sweeties have high contents of dietary fibers and antioxidant compounds. Diets supplemented with peeled sweeties
positively influence plasma lipid metabolism and plasma antioxidant capacity in patients suffering from hypercholesterolemia. Therefore, the
addition of peeled sweeties to a generally accepted antiatherosclerotic diet may be beneficial in prevention of atherosclerosis, mainly in
hypercholesterolemic patients.
D 2004 The Institute For Cancer Prevention and Elsevier Inc. All rights reserved.
Keywords: CAD prevention; Citrus fruits; Diets; Hypercholesterolemia; Plasma antioxidant activity
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